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KMID : 0878220000120010228
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Journal of Sasang Constitutional Medicine
2000 Volume.12 No. 1 p.228 ~ p.239
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Effect of Soumin Seonghyangjeongkisan Extract on Blood Pressure and RegioCerebral Blood Flow in Ratsal
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Abstract
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Purpose : For many years, Soumin Seonghyangjeongkisan(少陰人 星香正氣散, SJ) has been used in Sasang(四象) constitutional medicine as a therapeutic agent for cerebral disease. The effects of SJ on the vascular system is not well-know. The purpose of this study is to make it clear the effects of SJ and composing drugs on blood pressure(BP) and regional cerebral blood flow(rCBF).
Method : We measured BP with Pressure Transducer, rCBF with Laser-Doppler flowmeter. Propranolo and methylene blue were used to determine the mechanisms of SJ effects.
Results and Conclusion : BP was not affected by SJ in rats, and rCBF was significantly increased by SJ in rats. rCBF was increased by Folium Perillae(蘇葉), Rhizoma Atractylodis(蒼 ), pericarpium Arecae(大腹皮) and Rhizoma Arisaematic(南星), but decreased by Radix Saussurea(木香) in rats. The increase of rCBF is mediated by adrenergic β-receptor and guanylyl cyclase which is enzyme producing cyclic GMP.
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KEYWORD
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Soumin, Seonghyangjeongkisan, blood pressure, regional cerebral blood flow
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